To find a solution, start by ruling out the most common or obvious causes of depression.
Blood Testing
Has she been tested for obvious medical problems? As much as 10% of the population has thyroid problems. It's as common as wearing glasses or having high arches. Problems with glands and hormones are often caused by autoimmune diseases. Does her family have a history of type 1 diabetes, rheumatoid arthritis, chronic fatigue, grave's disease?
This is all checked with simple blood tests that should have been done years ago, but lots of doctors are idiots, so I don't like to assume that these problems have been ruled out.
Vitamins and Minerals
Starting right now, you can try giving her vitamins and iron. Having low iron makes a person feel tired all the time, and it's usually women who have this problem because they bleed more often. Vitamin B deficiency is uncommon in normal people, but vegetarians or vegans who don't know what they're doing can easily run short on B vitamins. Lack of B vitamins feels a lot like iron deficiency because iron and B vitamins are needed to carry oxygen in the blood. Lack of vitamins also has weird symptoms like bruising easily, having a swollen tongue, and tingling in the hands and feet.
Sleep Patterns
Does she sleep well? Having trouble falling asleep or staying asleep can really screw up a person's behavior. The simplest OTC drug to try is melatonin. If that doesn't work, give her an antihistamine that causes drowsiness, such as diphenhydramine or dimenhydrinate. More serious sleep problems need prescription drugs.
Drugs
If all of that stuff fails, move on to antidepressants.
Most Effective = MAOI drugs
Medium Effectiveness = TCA drugs
Least Effective = SSRI and SNRI drugs
These are not the only types of antidepressant, but they're a good start. Some of the more unusual antidepressants are bupropion (dopamine stimulant), trazodone (adrenergic and serotonergic sedative), and mirtazapine (histamine sedative).
Source: http://talkaboutmarriage.com/anxiety-depression-relationships/59489-wife-depressed.html
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